The dosing regimen is a single dose of 0.5 mL, the vaccine does not contain a preservative. People with bleeding disorders may have questions and concerns related to the variant coronavirus causing COVID-19 and the new COVID-19 vaccines, including any implications specific to their conditions. This is a scary time for all of us. I am also hetero factor V leiden. It should be noted that, immune tolerance therapy, treatment for hepatitis C, and HIV and other conditions including the use of immunosuppressive agents do not preclude a person from receiving the available vaccines. Following an extensive evidence review, the American College of Obstetricians and Gynecologists recommends that COVID-19 vaccines should not be withheld from pregnant individuals. COVID-19 Vaccines and Bleeding Disorders: Frequently Asked Questions (FAQs). Comirnaty contains mRNA, a kind of genetic material. I am curious Contactmm803 -were you were on blood thinners prior to your vaccine? Other monoclonal antibodies have been and are being developed as treatments for COVID-19 infections. Since I have the factor V mutation, I have chosen not to get a vaccine for COVID. The Johnson & Johnson COVID-19 vaccine was linked to an increased frequency of blood clotting, so I would not recommend that vaccine. Contact your hematologist or healthcare professional to plan to safely receive the vaccine. The vaccine is also authorized to provide a third primary series dose at least one month following the second dose for individuals in this age group who have been determined to have certain kinds of immunocompromise. 25 Shattuck Street Three COVID-19 vaccines two mRNA vaccines from Pfizer-BioNTech and Moderna and one recombinant, replication-incompetent human adenovirus serotype 26 (Ad26) vector vaccine from Johnson & Johnson/Janssen Biotech, have received emergency use authorization (EUA) in the United States from the Food and Drug Administration and are currently being administered to people in the US. The General Hospital Corporation. Talk to your physician or pharmacist for when your booster shot should be scheduled, and what you need to know to prepare. Can you mix the vaccines for your mRNA primary vaccination series? I also have heart disease and 1 stent in the L.A.D. 1. I would encourage anyone to spend some time on these sites, in addition to taking advantage of the use of Google Scholar to be able to see actual studies that have been published, if reading the publications that are meant for patients like us are not enough. I do all of this to reduce my risk of getting this terrible disease. Aside from COVID-19, Ive never seen anything else cause markedly elevated factor V, and Ive been doing this for 25 years, Van Cott says. Im glad you are choosing a modest serving size for your evening glass. The conditions on this list are in alphabetical order. The study was internally funded by Mass General. Importantly, the MGH investigators note that factor V elevation in COVID-19 could cause misdiagnosis of some patients, because under normal circumstances factor V levels are low in the presence of liver dysfunction or DIC. Now, as Massachusetts makes vaccines available for residents with two or more COVID risk conditions, many residents are trying to figure out if they qualify. The Janssen Biotech vaccine received emergency use authorization on February 27, 2021 from the U.S. Food and Drug Administration, the third vaccine for the prevention of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). UPDATED BOOSTER, A Novavax booster is available in limited situations Have any of the vaccines been approved by the FDA? They studied the levels of these clotting factors and other parameters in a group of 102 consecutive patients with COVID-19, and compared the results with those of current critically ill patients without COVID-19, and with historical controls. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. Furthermore, the vaccine elicited high levels of neutralizing antibodies demonstrating strong immunogenicity in a subset of adolescents one month after the second dose. This pointed the investigators to activity of factor V as well as factor VIII and factor X, two other major blood clotting protein factors. My drs felt that any vaccine was better than none, as the rate of blood clots if admitted to hospital with COVID goes up dramatically compared to the rate of blood clots linked to the vaccines - based on what I have read. I spent five days in an ICU on high flow oxygen after failing to respond to nasal cannula, a non rebreather mask, or BIPAP., then another day and a half in a telemetry bed. Webfor factor V Leiden mutation and prothrombin gene 20210 G/A mutation were both negative. The waveform can actually be a useful tool to help assess patients as to whether their clinical course is declining toward DIC or not, Van Cott said. My only health problem is high blood pressure, for which I take nifedipine and atenolol. Children aged 5 years can only get a Pfizer-BioNTech booster, and children aged 611 years can get a Pfizer-BioNTech or Moderna booster. One vaccine, the messenger RNA (mRNA) vaccine developed by Pfizer-BioNTech has been approved by the United States from the Food and Drug Administration on August 23, 2021, and will be marketed under the trade name of Comirnaty (koe-mir-na-tee). I looked at the math, and the risk of clotting from the vaccine is so much lower than the risk of clotting from COVID, it was the easiest health care decision I could make for myself in these crazy, scary times. UPDATED BOOSTER For this reason, and knowing the likelihood of clots with COVID regardless of prior experience or risk factors, I got vaccinated as soon as I was eligible in my state, and will get a booster as soon as I can. Its plausible that there may be genetic factors that increase the risk of the AstraZeneca vaccine in some people in a similar way, but at this stage, we dont know. I have participated in reddit AMAs hosted by World Thrombosis Day, that were a good opportunity to ask questions and get answers directly from international hematology expersts. These vaccines were developed very fast. Enable push notifications on your device. If you have too few platelets, less than 150,000 per microlitre, then you have a deficiency known as thrombocytopenia. In March 2020, in the early days of the COVID-19 pandemic in Massachusetts, Van Cott and colleagues found that a blood sample from a patient with severe COVID-19 on a ventilator contained factor V levels high above the normal reference range. And although yet to be confirmed, it seems the AstraZeneca vaccine, by causing blood clots, may be leading to low platelet levels in an extremely small number of people too. The lab tests that usually diagnose DIC were not helpful in these cases.. Are they safe? The vaccine does not contain a preservative. Search for condition information or for a specific treatment program. I just found out Im hetero for Factor V leiden. If you have a question about this please talk with your hematologist or healthcare professional. COVID infection, on the other hand, is strongly linked to abnormal blood clotting, for which you are at higher risk because of your factor V Leiden mutation and your history of a deep vein blood clot. A bleeding disorder neither increases the risk for getting coronavirus infection nor having a serious infection, being hospitalized, or dying if you are infected. As the virus mutates or changes, these changes may be in the Spike protein causing the vaccines to be less effective against these mutated strains of the virus. Pfizer-BioNTech Some vaccines must be administered using the accompanying needlesyringe combination, and so the use of an alternative needle may not be possible or desirable. If you have a bleeding disorder, there are no contraindications to being vaccinated with any of the three vaccines now available via EUA status for intramuscular administration. Invite them to speak with their pediatrician for additional information. About 5% of people categorised as white have this mutation, though it is much less common in other ethnic groups. Then I got COVID-19 in October 2020, but recovered with only mild symptoms. PRIMARY SERIES The safety, effectiveness, and benefit of the third primary dose in people who are moderately or severely immunocompromised continues to be evaluated. These questions should not deter anyone from receiving a vaccine. I did talk with my primary care provider and hematologist and both whole heartedly supported my getting vaccinated. Its a reminder of how complex the blood and clotting is, with multiple parts of the process that can be disrupted. I will update my post over the next two weeks if there are any new developments -.hopefully nothing exciting! Now, there were some differences in the primary efficacy against all forms of COVID-19. Both the FDA and CDC have approved the Moderna COVID-19 vaccine for children ages 5 and younger, and the Pfizer-BioNTech COVID-19 vaccine for those ages 4 and under. The vaccine contains a nucleoside-modified messenger RNA (modRNA) encoding the viral spike (S) glycoprotein of SARS-CoV-2 formulated in lipid particles. WebFactor V Leiden (FVL) is a change in your genes that affects one of the clotting factors in your blood and keeps your body's blood -clotting process from working right. Patients with severe COVID-19 disease caused by the SARS-CoV-2 virus can develop blood clots in medical lines (intravenous lines, catheters, etc), and in arteries, lungs, and extremities, including the toes. I'm 54 and not in a hotspot and debating AstraZ vs waiting for Pfizer. Also wondering if our condition meets the provincial gov't "high risk conditions", Did your docs have an opinion on which vaccine given our condition? With this in mind, its worth remembering that while there is a small risk of clotting in some individuals who take the AstraZeneca vaccine, this clotting risk is much less than with many other things, including contraceptive pills and significantly less than the risk of clotting after a COVID-19 infection. The mechanisms behind vaccine-related having a genetic mutation that affects a specific clotting factor called factor V Leiden is its important to note that At this time Im very skeptical about receiving a COVID-19 vaccine because of my reaction to the hep a vaccine. Then, ask your child to share how they feel about the COVID-19 vaccine and their health. What are the risks of vaccinating people who are moderately or severely immunocompromised with a third primary dose? Their findings, based on studies of patients with COVID-19 in Mass General intensive care units (ICUs), point to disturbances in factor V activity as both a potential cause of blood clotting disorders with COVID-19, and to potential methods for identifying at-risk patients with the goal of selecting the proper anticoagulation therapy. - In comparison, folks with influenza in the same period had a rate of 3.83 per million, and peop,e who received an mRNA vaccine (6.67 per millino). COVID-19 Vaccines for People Who Are Moderately or Severely Immunocompromised. Their findings are: - Incidence of CVT after COVID diagnosis was 42.8 per million, including 35.3 per million first diagnosis. As with vaccines for other diseases, you are protected best when you stay up to date with your COVID-19 vaccines for your age group: COVID-19 vaccine and booster recommendations may be updated as CDC continues to monitor the latest COVID-19 data. SOUNDS TO ME LIKE THEY DON'T WANT THIS INFORMATION TO GET OUT. People who are moderately or severely immunocompromised who have low or no protection after two doses of mRNA vaccines may have an improved immune response after a third primary dose of the same vaccine. Is it safe to get the vaccine with my condition ? Blood clots are also a complication of COVID-19 1. These typically appear between four and 20 days after vaccination. Did you qualify because you live in a hotspot or meet the age threshold? Would I be in a priority group to receive the vaccine with a bleeding disorder? https://pubmed.ncbi.nlm.nih.gov/32271988/). Because of this, comparisons have been drawn with the contraceptive pill, which carries a greater relative risk of clots. The Janssen Biotech vaccine contains a type of a human adenovirus. Most commonly, side effects tend to be mild and usually only last a day or two. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/JJUpdate.html). Death rates were significantly higher for patients with lower levels of factor V (30 percent vs. 12 percent), with evidence that this was due to a clinical decline toward a DIC-like state. At age 90+, you are entitled to do what you want, and that includes making health decisions that might not be the most ideal for overall health. Thrombocytopenia can be inherited, acquired through lifestyle factors over time (such as poor diet combined with alcohol) or brought on by medicines or infections. This was a paused based on 15 reports. Executive Master of Public Administration, After oil: the challenge and promise of getting the world off fossil fuels, Advanced Clinical Anatomy - Postgraduate Course, Graduate Certificate in Clinical Informatics and Digital Health, All states for online course , Queensland, Committee Member - MNF Research Advisory Committee, PhD Scholarship - Uncle Isaac Brown Indigenous Scholarship. Brisbane, Queensland, Graduate Certificate in Clinical Informatics and Digital Health An abnormality in the affected individual's DNA results in the production of an abnormal form of Factor V. The amount of abnormal Factor V, and the severity of disease, depends on the presence of one or Patients with severe COVID-19 caused by the SARS-CoV-2 virus can develop blood clots in medical lines, such as intravenous lines and catheters, and in arteries, lungs and extremities, including the toes. I got the Pfizer vaccine three days ago and after reading this I think my BP just shot uplol. There are a lot of things that still need to be explored. When will the vaccine be available for younger children below age 12 years? They help us to know which pages are the most and least popular and see how visitors move around the site. From what I have read the J&J has a risk for blood clots. As more people get vaccinated, the data generated will be clearer as well (including stats on being on blood thinners prior to the vaccine). All rights reserved. Of note, more people experienced these side effects after the second dose than after the first dose, so it is important for vaccination providers and recipients to expect that there may be some side effects after either dose, but even more so after the second dose. Four days later, this patient developed a saddle pulmonary embolism, a potentially fatal blood clot occurring at the junction of the left and right pulmonary arteries. The mRNA is used by the body to make a mimic of one of the proteins in the virus that causes COVID-19. Factor products that use PEG to extend the half-life of the factor product or any factor products are not a reason to not take a vaccine unless you have had a reaction to PEG. I BET IT'S HAPPENING FREQUENTLY. Similarly, COVID-19 vaccines should be offered to women who are breast feeding. Clotting is a complex system. The second is that in your 90s, your ability to metabolize alcohol isnt what it was in your 20s, so a small drink for you now is equivalent to a larger drink for a person much younger than you. At least 2 months after 2nd dose or last booster, A J&J/Janssen booster is available in limited situations. I believe this was used of God and was providential. UPDATED BOOSTER